RHEA is a database of biochemical reactions, initially populated
with data from IntEnz.
Its motivations and initial specification can be found in the
IntEnz documentation web site.
- Use of a
for referencing every chemical compound in IntEnz.
Existing reactions in IntEnz - stored as free text -
would be parsed to extract and map every compound,
for every reaction in IntEnz. One reaction could be
referenced by several different EC numbers, avoiding
redundancy in the database.
- Having unique identifiers for reactions, a new
identifier for enzymes based on the catalyzed
reactions could be built. This new ID would be
completely independent from the EC classification.
- Being unique, RHEA reactions can belinked from/to
other reaction databases: Reactome, KEGG reaction,
- Portability: reactions should be easy to
import/export in common formats. To this end,
BioPAX has been
The main RHEA subproject is the active development of a
reaction ontology, requested independently by different
people during the meetings held to gather requirements and
suggestions about the projected IntEnz reaction database.
Among the existing reaction ontologies,
has been chosen to this end.
In order to manage this and other ontologies,
was conceived as a user friendly, multiuser system.